Angiogenesis, which occurs in the site of anoxic tissue, can lead to the formation of new blood vessels and is crucial for the self-compensation in response to ischemia from coronary stenosis or occlusion.[1] Several growth factors are closely associated with angiogenesis such as angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and vascular endothelial growth factor. Here, ANGPT2 is linked to ischemia.