It may also have potential to be a biomarker of CIN, since one study showed that serum UT-II levels of post-PCI are significantly correlated with the amount of contrast media in patients undergoing PCI.[45] Oddly, plasma UTN is found to be an inverse predictor of cardiovascular mortality in patients with CKD.[46] Therefore, it will be intriguing to further assess the relationship of Ang-2 with these potential mediators after PCI, and their associations with the occurrence of CIN and subsequent adverse cardiovascular events in the future. The gene discussed is ANGPT2; the disease is chronic kidney disease.