Ang-2 is stored in endothelial Weibel-Palade bodies and can be rapidly released through endothelial activation.[5] The only known inhibitor of Ang-2 exocytosis from Weibel-Palade bodies is nitric oxide,[29] which has decreased availability in patients with CIN. Here, ANGPT2 is linked to cervical squamous intraepithelial neoplasia.