The ischemic myocardium is probably dominant factor influencing the Ang-2 levels of pre-PCI, which have been demonstrated only to be correlated with severity of coronary artery stenosis.[7,8] After the relief of myocardial ischemia by PCI and the different extent of renal injury by contrast agent, the status of renal function may turn to be major influence factor of serum Ang-2 levels of post-PCI. The gene discussed is ANGPT2; the disease is coronary stenosis.