It is recently reported that Ang-2 is an independent predictor of major adverse cardiovascular events in CKD patients.[10] In addition, previous studies have shown that the elevated Ang-2 level is an indicator of abnormal cardiac structure and vascular atherosclerotic burden in patients with CKD,[35,36] which supported our hypothesis that the Ang-2 released from 1 dysfunctional organ may accelerate the disease progress of distant organ. This evidence concerns the gene ANGPT2 and chronic kidney disease.