High level of Ang-2 can result in the destabilization of endothelial cell junctions to enhance new vessel branching and sprouting.[4] Ang-2 is stored in the Weibel-Palade bodies within the endothelial cells and can be rapidly released upon various stimuli.[5] Ang-2 expression is significantly up-regulated in ischemic or necrotic myocardium.[1,6] Clinical studies have indicated that peripheral blood Ang-2 concentrations are elevated in patients with CAD and are associated with the severity of coronary artery stenosis.[7,8]. This evidence concerns the gene ANGPT2 and coronary stenosis.