UTS2 and endothelial dysfunction: Studies suggested that it can induce a pro-atherothrombotic phenotype in human coronary endothelial cells and can be used as a biomarker predicting the adverse cardiovascular events.[41,42] Urotensin II (UT-II), which plays an important role in CKD,[43] is involved with endothelial dysfunction and coronary thrombosis.[44] It probably represents a key link between CKD and CAD.