On the other hand, in patients with CAD, the Ang-2 released from the heart may also exacerbate the renal function by enhancing the glomerular endothelial apoptosis, aggravating the tissue edema and leading to the albuminuria.[37] Therefore, altered angiopoietin/Tie-2 system may cause a cascade leading to the systemic endothelial dysfunction and subsequent organs dysfunction. Here, TEK is linked to coronary artery disorder.