By the way, this is suggestion of many experts in that field, since loss of PMS2 almost always accompanies loss of MLH1 (rare cases of isolated PMS2 loss are due to PMS2 germline mutations and would not influence our results) and MSH6 is mostly lost with MSH2 (uncommon isolated MSH6 loss is usually in endometrial cancer and also therefore unlikely). This evidence concerns the gene MSH2 and endometrial cancer.