So the question of whether, and if so, to what extent, the activity of angiogenesis depends on genetic integrity of the tumor is of great importance in the era of personalized cancer treatment.[41,42] The current study revealed significantly higher serum levels of the VEGF protein and higher numbers of circulating EPCs as % of WBC in the cohort of 80 patients with CRC liver metastases in comparison to the cancer-free individuals. This evidence concerns the gene VEGFA and neoplasm.