The level of serum VEGF concentration was higher only in the patients, both those with MSI-H and those with MSS, who had a positive family history of any cancer (X2 = 2.17, P < .02), and in patients with the onset of liver metastases earlier than 12 months after the operative treatment of the primary lesion (X2 = 6.81, P < .03). Here, VEGFA is linked to cancer.