This binding inhibits the migration and proliferation of endothelial cells induced by VEGF thus reducing angiogenesis and micro-vessel density in the tumor.[2,3] Apatinib has also proven to be safe and effective in the treatment of advanced gastric cancer.[4] The application of the drug in treating many solid tumors such as hepatocarcinoma, breast cancer, lung cancer, and esophageal carcinoma is being explored.[5]. The gene discussed is VEGFA; the disease is neoplasm.