Recently, the prognostic effect of SOX11 appeared conflicting.[22–25] Thus, 2017 International Conference on Malignant Lymphoma in Lugano brought up that SOX11 may not have prognostic value.[26] However, the technique used in chromosome and genetic testing is more complex and high-cost, prognostic stratification based on the clinical characteristics may be more economical and convenient. The gene discussed is SOX11; the disease is lymphoma.