The morphological and genetic characteristics of these cell lines are well- known already.17 In continuation of our scientific works on the evaluation of the anti-proliferative activity of the Iranian Medicinal plants,18-25 this study investigated the cytotoxic activity of n-hex, DCM and methanol (Met) extracts of the aerial parts of E. billardieri against PANC-1 cancer cell lines via Bax and cyclin D1 mRNA expression. The gene discussed is CCND1; the disease is cancer.