CCND1 and cancer: Several observational studies have suggested that cyclin D1 plays a key role in promoting the growth of certain human malignancies.6,28 By considering various findings, nowadays it has been established that deregulation of cyclin D1 expression has contributed to the loss of cell cycle control and enhance tumorigenesis.29 A correlation has previously been pointed out between increased cyclin D1 and cancer formation.30,31 Based on the results of this study, the DCM and n-hex extracts of E. billardieri reduced cyclin D1expression in treated cancer cells with no effect on the normal cells.