Two main strategies are currently followed to cure the HIV-1 infection: 1) a functional cure, in which the viral replication is controlled while latent reservoir still remains; e.g. the impairment of the CCR5 receptors, and 2) a sterilizing cure, in which even viral traces are eliminated from the infected cells.18 Individuals carrying a 32-bp deletion in their CCR5 gene (CCR5∆32) are instinctively resistant to HIV-1 infection. The gene discussed is CCR5; the disease is HIV-1 infection.