MADD and infection: Disruption of SPCS1 processing pathway reduced the infection level of all flaviviridae members.8 Moreover, orthologous functional genomic CRISPR-Cas9 screening revealed various host factors involved in virus entry (AXL), endocytosis (RAB5C, RABGEF) and transmembrane protein processing and maturation (EMC) which are associated with the infection of the DENV and ZIKV.9 TLR7/8 agonist R848 strongly restrains ZIKV replication.