Overexpression of this protein is often correlated with DNA hypermethylation, higher cell growth rate, genomic instability and immortalization which lead to aggressive behavior of tumors.40 Commensurate with these statements, MYCN gene can be considered as an important target for cancer therapy with novel therapeutic inhibitors such as PNA to manage proliferation and apoptosis pathways and reduce the malignant behavior of the tumor.39,41 The possibility of PNA-based strategy for inhibition of MYCN transcription was previously examined by Tonelli and colleagues. Here, MYCN is linked to cancer.