Both the low cost and increased availability of point-of-care CRP tests in the primary care setting warrant further investigation into the potential use of CRP as a risk biomarker for lung cancer development.8, 9, 10 The primary objective of our study was to comprehensively investigate the relation between circulating hsCRP concentration and the risk of lung cancer for never, former, and current smokers. The gene discussed is CRP; the disease is lung carcinoma.