A recent mouse study showed that depletion of both TET1 and TET2 resulted in impaired self-renewal and differentiation of BMSC, which was associated with a significant osteopenia phenotype and supports the observation that TET1 and TET2 expression is reduced in OXV mice leading to decreased 5hmC levels in BMSC and impaired bone formation [9]. The gene discussed is TET2; the disease is Osteopenia.