Oct4 participates in different pathways to determine a cell’s fate [14] and its expression has been described and correlated with tumorigenesis, chemotherapy resistance, metastasis, aggressiveness and poor clinical outcomes in medulloblastoma and bladder, gastric, ovarian, lung, colorectal and hepatocellular carcinomas, among others [17–22]. The gene discussed is POU5F1; the disease is hepatocellular carcinoma.