For this reason, we suggest that, in accordance with the role of Oct4 in the mammal embryonic development, this biomarker may promote undifferentiated states and cellular proliferation in NBTs, thus increasing tumour aggressiveness through morphological physical stress magnification related to extracellular matrix and cytoskeleton modifications in NB and nodular GNB, similar to the Oct4A role in ovarian cancer [43]. This evidence concerns the gene POU5F1 and neoplasm.