Oct4 participates in different pathways to determine a cell’s fate [14] and its expression has been described and correlated with tumorigenesis, chemotherapy resistance, metastasis, aggressiveness and poor clinical outcomes in medulloblastoma and bladder, gastric, ovarian, lung, colorectal and hepatocellular carcinomas, among others [17–22]. This evidence concerns the gene POU5F1 and medulloblastoma.