As a supplement to the investigation of TGR5 agonism by RDX8940 in mice fed a Western diet, the effects of direct GLP-1 and GLP-2 agonism on hepatic analytes and characteristics in mice fed an HFCD (a model of NAFLD and mild Type 2 diabetes) were evaluated, using the GLP-2 agonist, teduglutide, and the GLP-1 agonist, liraglutide. The gene discussed is GPBAR1; the disease is type 2 diabetes mellitus.