TRPV4 is an important regulator of intracellular Ca2+ concentration in cardiac fibroblasts.18 It has also been reported that TRPV1 was up‐regulated in pathological myocardial hypertrophy.19 According to our previous study, TRPV3 activation exacerbated cardiac fibrosis by promoting cardiac fibroblast proliferation through TGF‐β1/CDK2/cyclin E pathway in the pressure‐overloaded rat hearts.20 Interestingly, the overall sequence of TRPV3 has 40% homology to TRPV1.21 Therefore, we speculate whether TRPV3 is also involved in the occurrence of cardiac hypertrophy. The gene discussed is TRPV4; the disease is cardiac hypertrophy.