DNER and neoplasm: Pomalidomide is another small molecule for the induction of E3 ubiquitin ligase used for the PROTAC design.1 The pomalidomide‐based PROTAC ARV‐825 was proved to function on different immune cells46 and greatly induced apoptosis in tumour cell line.47 Almost at the same time, Winter et al used the phthalimide as a moiety to hijack the cereblon E3 ubiquitin ligase to degrade BET family proteins.48 They used their selected direct‐acting inhibitor of BET bromodomains JQ1, through its carboxyl group and the aryl ring of thalidomide, to form a bifunctional hybrid molecule PROTAC.