Finally, those authors demonstrated that cotreatment of ARV‐771 with other drugs including ibrutinib, venetoclax (a BCL2‐antagonist), and palbociclib (a CDK4/6 inhibitor) had a synergistical effect on the induced apoptosis of MCL cells.70 Consistent with the about work, Qin later on discovered QCA570 as a potent PROTAC against BET proteins.71 More excitingly, Zhou et al designed a new PROTAC against BET family proteins and obtained a compound with 30pM concentration for effectively degrading BRD4.72 The gene discussed is DNER; the disease is mantle cell lymphoma.