In GBM, overexpression of miR-221, miR-10b, miR-130a, miR-125b, miR-9-2, and miR-21 has been reported.27 Among these miRNAs, miR-10b, which regulates homeobox D10 (HOXD10), and miR-21, which targets RECK, are important in facilitating glioblastoma invasion.28,29. This evidence concerns the gene HOXD10 and glioblastoma.