Hox superfamily genes, including HOXD10, encode transcriptional factors regulating cell differentiation and morphogenesis during development.42 Dysregulation of the Hox gene disrupts various signaling pathways related to tumorigenesis and metastasis.43 A positive correlation exists between reductions in HOXD10 mRNA and increased malignancy of breast cancer and endometrial adenocarcinoma.44 Forced expression of HOXD10 mRNA strikingly suppresses tumor motility and invasion in breast cancer,45 suggesting a potent inhibitory role of HOXD10 in tumor invasion. The gene discussed is HOXD10; the disease is breast carcinoma.