In this study, we addressed a part of this long-standing issue using the OncoMir library infection system and found that miR-23a directly targets the HOXD10-3′UTR and promotes tumor cell invasion by elevating the expression levels of invasion- and glial-mesenchymal transition (GMT)-related genes and inducing polarity of focal adhesions in GBM (Fig. 6c). The gene discussed is HOXD10; the disease is glioblastoma.