Among genes implicated in RCC, BAP1 and SETD2 were down regulated in aggressive ccRCC (P < 0.05), but other genes, PBRM1, KDM5C, VHL, PTEN, and MTOR, were not associated with aggressive ccRCC (Supplementary Table 1). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.