Considering only mRNAs that were differentially expressed with FC >1.50 or <0.67 and remained significant after adjustment for multiple comparisons, four mRNAs (CNTF, PIAS2, SOCS6 and IFNE) were uniquely dysregulated in MSS tumors (Supplementary Table 2), and eight mRNAs (IL21R, JAK3, CISH, GFAP, IL2RG, IL12A, LEP and HRAS) had dysregulated expression for MSI-specific tumors (Supplementary Table 3). This evidence concerns the gene IFNE and Marinesco-Sjogren syndrome.