LAG3 and neoplasm: Aberrant LAG-3 expression has been found in a broad spectrum of human tumors such as melanoma, NSCLC, colorectal cancer, breast cancer, hepatocellular carcinoma, follicular lymphoma, head and neck squamous cell carcinoma, etc, which is significantly associated with aggressive tumor progression and clinicopathological characteristics (summarized in Table 1) [32, 34–48].