Analysis of the cell secretome revealed specific cell-type differences (MDA-MB-231 cells: increased cancer attenuator follistatin and reduced pro-inflammatory cytokines IGFBP-1, MCP-1, MIP-1α, IL-6; MCF7: increased cancer signals osteopontin, sHER-2, VEGF-A, uPA, EGF amongst others). The gene discussed is SPP1; the disease is cancer.