Targeting cell-matrix interactions in dormant niches has also been tested with one study reporting that administration of flavopiridol selectively abrogated dormant clones of MCF7 and T47D breast cancer cells via suppression of integrins α5 and β1, reduced adhesion to fibronectin, diminished Akt phosphorylation and total protein levels of ERK1/2 and p38 [181, 182]. The gene discussed is AKT1; the disease is breast carcinoma.