VEGFA and cancer: Drugs that suppress HIF-1α expression (e.g. topotecan, irinotecan, Adriamycin) or VEGF expression (irinotecan, 5-FU, oxaliplatin, paclitaxel and docetaxel) in different cancer cell lines could possibly be administered metronomically to suppress angiogenic outgrowth and prolong angiogenic dormancy.