In a landmark study by Ghajar et al., breast cancer cells were co-cultured in lung-mimetic or bone-marrow mimetic perivascular niches and thrombospondin-1 (TSP1) secreted by stable endothelial networks was observed to maintain tumor cells in a dormant, non-proliferative state, with a possible supportive role of bone morphogenetic protein 4 (BMP4) [42, 116] (Fig. 3f). This evidence concerns the gene BMP4 and neoplasm.