DMD and myotonic dystrophy type 2: Additionally, a degenerative miRNA, miR-135a, and an inflammatory miRNA, miR-223, are involved in the pathological pathways activated in skeletal muscle damage and regeneration by both dystrophin absence and acute ischaemia in MDX mice and in DMD patients.19 Furthermore, in Myotonic Dystrophy Type-2 (DM2), an autosomal dominant disease that mainly affects skeletal muscles, the heart and the central nervous system, many miRNAs are deregulated, and miR-125b and miR-193b are decreased.12 Therefore, altered miRNAs are responsible for muscle diseases.