PNPLA6 and Guillain-Barre syndrome: Wang et al. showed that miR-155 is down-regulated in peripheral blood mononuclear cells (PBMCs) from GBS patients and that silencing miR-155 profoundly promotes the production of Th1-type cytokines in vitro.13 Interestingly, delayed onset distal polyneuropathy is a consequence of severe intoxication due to the inhibition of the neuropathy target esterase (NTE) enzyme,14 also known as patatin-like phospholipase domain-containing 6 (PNPLA6), in nervous tissues by certain organophosphorous compounds.