HK2 and neoplasm: Indeed, inhibitors of glycolytic enzymes such as hexokinase 2 (HK2) [5,6], phosphofructokinase 2 (PFK2) [7], pyruvate kinase M2 (PKM2) [8], lactate dehydrogenase A (LDHA) [9], and pyruvate dehydrogenase kinase (PDK) [10] show anti-tumor effects.