Epidemiology studies show that FTO SNPs (including rs9939609, rs17817449, rs8050136, rs1477196, rs6499640, rs16953002, rs11075995, and rs1121980) are associated with increased FTO expression, overweight/obesity and increased risk of various types of cancers, including PCa [328]. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.