COX17 and neoplasm: Our RT-qPCR analysis confirmed that mRNAs of COX7B and COX17 genes, which protein products participate in Complex IV, were down-regulated Interestingly COX17 was proposed as the therapeutic target in lung cancer [42], while COX7B was shown to be overexpressed in carcinoma and its expression was decreased by anti-tumor agents in the glioblastoma treatment [43].