Autophagy, a catabolic digestion process of cellular macromolecules and organelles, plays an important role in protecting cells against adverse conditions such as oxidative stress, hypoxia, and starvation; events observed during glaucoma.19 The process makes use of cargo receptors, such as microtubule-associated protein 1A/1B-light chain 3 (LC3) and SQSTM1/p62, recognizing ubiquitinated cellular waste and initiating its engulfment by the autophagosome. The gene discussed is SQSTM1; the disease is glaucoma.