FOLH1 and cancer: While not specifically investigated in the current study, the utility of detecting cHSA or PSMA-positive malignant cancer cells in systemic circulation could provide a non-invasive method to identify micrometastatic disease, as well as to serially monitor for disseminated disease progression; analogous to the quantification of PSMA amplicons in circulating blood in men diagnosed with prostatic carcinoma [28, 29].