BRD2 and Alzheimer disease: In our SE analysis during 0-back, the CH-PAT group had significantly higher alpha SE during the active ERD time window than CH-NAT, specifically in the frontal region (p < 0.05), indicating they have more “noisy” brain alpha signals while performing this simple task; this suggests a frontal hyperactivity or compensatory mechanism was detectable in the cognitively healthy group with CSF biochemistry that is consistent with AD-like pathology.