FCGR3A and cancer: CD16 engagement has been proven to play a critical role in ADCC mediated by several mAbs clinically approved to treat cancer.41–47 To determine whether tumor cell lysis in the presence of NEO-201 is mediated by ADCC and that ALT-803 is able to enhance NEO-201-mediated ADCC, NK cells isolated from a healthy donor were treated with ALT-803 (25 ng/mL) or vehicle control for 48 h.