For instance, lncRNA RHPN1-AS1 is downregulated in gefitinib-resistant patients, and NSCLC cell lines and RHPN1-AS1 knockdown promote the gefitinib resistance; however, RHPN1-AS1 upregulation activates the gefitinib-resistant NSCLC cells (Li et al., 2018). This evidence concerns the gene RHPN1 and non-small cell lung carcinoma.