The density of the tumor‐infiltrating CD8+ T cells was significantly associated with location in the tumor (Figure 2), suggesting that the number of CD8+ T cells significantly number of CD8+ T cells significantly increased in the invading edge and periphery of the tumor as compared to the center of the tumor, in both the stroma and parenchyma (P < 0.01 and P < 0.01, respectively). This evidence concerns the gene CD8A and neoplasm.