The aim of this study was to conduct immunohistochemical evaluation of the density and location of five types of CD8+ cytotoxic T‐cell infiltrates, including those located in stroma in the center of the tumor, parenchyma in the center of the tumor, stroma in the invading tumor edge, parenchyma in the invading tumor edge, and periphery of the tumor, to investigate their prognostic relevance in OSCC. This evidence concerns the gene CD8A and neoplasm.