Some authors have indicated that immune cells infiltration affected OS, DSS, and DFS.15, 19, 33 Higher CD4+ cell levels was an independent predictor for improved OS and DSS in 278 patients with HNSCC who received heterogeneous treatment strategies.18 In contrast, Balermpas et al,19 showed that high CD3+ and CD8+ T‐cell density were associated with significantly increased OS and PFS in patients receiving definitive chemoradiotherapy, while neither CD4+ nor FoxP3+ immune cell density showed significance for the clinical outcome. Here, CD4 is linked to head and neck squamous cell carcinoma.