The authors have emphasized in a previous paper that T cells in OSCC samples preferentially accumulate at tumor stroma and the tumor periphery.9 Because the invasive tumor edge is the first line of defense against cancer proliferation and metastasis, these observations have led to the hypothesis that direct and indirect effector CD8+ T cells infiltrate the parenchyma or stroma of different anatomical areas, such as the center of the tumor, invading tumor edge, or tumor periphery. This evidence concerns the gene CD8A and cancer.