CD8+ T cells can also recognize tumor antigens processed by the stroma,40 and activated CD8+ T cells secrete cytokines that induce cancer cell senescence and play essential roles in the control of anticancer immune responses and tumor growth.41 Thus, it is not surprising that indirect cytotoxic activity of CD8+ T cells may occur at peripheral stroma of the tumors. The gene discussed is CD8A; the disease is cancer.