Loss of C/EBPα expression in the villus cells is likely to occur by epigenetic mechanisms, potentially by DNA methylation, as observed in leukemic cells, which also demonstrates the central importance of C/EBPα expression in other neoplasms (Bennett et al, 2007; Hackanson et al, 2008; Jost et al, 2009; Lu et al, 2010; Lin et al, 2011; Di Ruscio et al, 2013; Gao et al, 2015). Here, CEBPA is linked to neoplasm.