Low C/EBPα levels have been observed in breast cancer (Gery et al, 2005), and there is epigenetic silencing in acute myelogenous leukemia (Hackanson et al, 2008) which together with our data suggest a general role of C/EBPα as a tumor suppressor gene. This evidence concerns the gene ENSG00000279284 and acute myeloid leukemia.