CXCR2 and asthma: Prior data suggested that activation of CXCR2 resulted in increased airway neutrophilia, thus contributing to the pathogenesis of non-eosinophilic asthma, but a recent trial with a CXCR2 antagonist in severe neutrophilic asthma (sputum neutrophils > 40%) not showed a significant improvement in asthma outcomes despite the reduction of sputum neutrophilia [72].