For this purpose, we investigated the direct effect of n-3 and n-6 PUFAs on promoter methylation status of epidermal growth factor-like domain 7 gene (EGFL7), the host gene of miR-126, and protein expression level of VEGF, as a well target of miR-126, in a panel of five well-characterized colorectal cancer cell lines. Here, VEGFA is linked to colorectal cancer.