SOX2 protein was expressed in optic nerve hypoplasia and abnormalities of the central nervous system [63], STAT1 was expressed during mycobacterial and viral infections [64], TUBB3 was related with fibrosis and cortical dysplasia and brain deformities, AKT1 was expressed in breast cancer, colorectal cancer, ovarian cancer, and schizophrenia [65] and CTNNB1 was expressed in colorectal cancer, hepatocellular carcinoma, ovarian cancer, and mental retardation [66]. The gene discussed is TUBB3; the disease is colorectal cancer.