TP53 and cancer: Alternatively, the clinical and molecular similarities occurring between advanced BRAF mutant traditional serrated adenomas (TSAs) and BRAF mutant/MSS cancers, such as similar gender distribution, propensity for CIMP, and mutant p53 [9, 10, 54, 55], strengthen the proposal that TSAs most likely serve as precursor lesions for BRAF mutant/MSS cancers [54] (Figure 2).