BRAF and cancer: In addition, alternative aberrations found in BRAF mutant/MSI lesions to activate the Wnt pathway include methylation of Wnt antagonists such as AXIN2 [76]; and SFRP4, DKK1, and WNT5A, the latter of which regulates the noncanonical Wnt pathway, were found to be methylated in BRAF mutant/MSI/CIMP-positive cancers [77, 78].