Therefore, intensive first-line FOLFOXIRI chemotherapy (consisting of a triple combination of 5-fluorouracil, irinotecan, and oxaliplatin) may be an efficient therapy approach as it showed improved response rates compared to administration of FOLFIRI (consisting of 5-fluorouracil and irinotecan only) in late-stage BRAF mutant cancer [127, 128]. Here, BRAF is linked to cancer.