According to hierarchal clustering analysis (Fig. 2) and KEGG network analysis (Fig. 3), the proteins Interleukin-1 receptor-like 1 (IL1RL1, 10.62-fold) and thrombospondin 1 (THBS1, 1.82-fold) were differentially expressed in HIV/AIDS patients between the TM-positive group and the TM-negative control group. The gene discussed is IL1RL1; the disease is AIDS.