IL1RL1, which is a member of the Toll-like receptor superfamily based on the structure of its intracellular Toll/interleukin-1 receptor (TIR) domain, has considerable prognostic value and is used to aid in risk stratification to identify patients who are at high risk of mortality and rehospitalization among patients diagnosed with heart failure [38–40]. This evidence concerns the gene TLR4 and heart failure.