TGFB1 and peeling skin syndrome: In this study, we investigated the relationship between TGF-β1/SMAD/Snail signaling and EMT-dependent fibrosis in pSS SGEC, using TGF-β1 treatment in human healthy SGEC as control, and analyzed the importance of TGF-β1/SMAD proteins and EMT-related molecular markers in clinical specimens from pSS patients.