Our study also revealed the potential use of circulating miRNAs-based tools for predicting type 2 diabetes development in clinical practice, showing a small but higher added predictive value to the usual clinical variables used, such as age, gender, BMI, HDL-C, TG, HbA1c, fasting glucose and fasting insulin, than the predictive value added by indices derived from OGTT, such as DI, MISI, ISI, HIRI and IGI, to these variables. The gene discussed is INS; the disease is type 2 diabetes mellitus.