Nevertheless, in contrast to the study by Willeit et al.18, which focused on miR-122 to evaluate the risk of T2DM, our study included four miRNAs, which were combined with several clinical variables, such as age, gender, BMI, HDL-C, TG, HbA1c, fasting glucose and fasting insulin; this allowed us to build predictive models by adding miRNAs, which increased the predictive power of the traditional clinical parameters. The gene discussed is INS; the disease is type 2 diabetes mellitus.