Our findings that the ripoptosome contributes to mitosis are consistent with earlier reports demonstrating that Casp8 is essential for maintaining chromosome stability, suppressing B cell lymphomagenesis (Hakem et al., 2012), restraining oncogene-induced transformation (Krelin et al., 2008), and acting as driver mutation in breast cancer (Stephens et al., 2012); also, it is frequently found to be mutated or lost in different cancer types (Hopkins-Donaldson et al., 2003, Martinez et al., 2007, Soung et al., 2005b). Here, CASP8 is linked to cancer.