This, together with our analysis that mRNA levels of RIPK1 are associated with aneuploidy in breast, lung, and colon cancer, strongly suggests that Casp8- and RIPK1-mediated regulation of PLK1 is required for the maintenance of chromosome stability, consequent aneuploidy, and suppression of cancer (at least in the B cell lineage for Casp8). This evidence concerns the gene CASP8 and cancer.