CASP8 and hepatocellular carcinoma: Accordingly, deficiency of Casp8 facilitates cellular transformation in vitro (Krelin et al., 2008), acts as driver mutation in breast cancer (Stephens et al., 2012) and B cell lymphoma (Hakem et al., 2012), and is frequently found to be mutated in hepatocellular carcinomas (Soung et al., 2005b) and advanced gastric cancer (Soung et al., 2005a).