Accordingly, deficiency of Casp8 facilitates cellular transformation in vitro (Krelin et al., 2008), acts as driver mutation in breast cancer (Stephens et al., 2012) and B cell lymphoma (Hakem et al., 2012), and is frequently found to be mutated in hepatocellular carcinomas (Soung et al., 2005b) and advanced gastric cancer (Soung et al., 2005a). Here, CASP8 is linked to breast carcinoma.