The up-regulated TF ZFHX3 targets seven genes in module AD_M25, where two genes OAS1 and RSAD2 are detected in infection pathways, and the other five genes FAM122B, SAMD9, TRIM21, USP18 and IFIT3 are also known to be related to infectious disease (Fig. 4). The gene discussed is SAMD9; the disease is infection.