USP18 and viral infectious disease: As for the other genes, SAMD9 has been reported as an innate host antiviral stress response element that participates in the formation of antiviral granules [24]; TRIM21 was reported to promote response to viral infections [25]; USP18 plays a role in innate immunity to viral infection [26, 27]; IFIT3 also involved in antiviral functions according to previous research [28, 29], and FAM122B is new here to be associated with infections.