The up-regulated TF ZFHX3 targets seven genes in module AD_M25, where two genes OAS1 and RSAD2 are detected in infection pathways, and the other five genes FAM122B, SAMD9, TRIM21, USP18 and IFIT3 are also known to be related to infectious disease (Fig. 4). Here, TRIM21 is linked to infectious disease.