SHBG and cancer: Among those 14, seven were previously reported, including FBLN1 (Fibulin-1), a tumor suppressor gene in HCC [35], SHBG (sex hormone-binding globulin), a prediagnostic risk marker for HCC [36], and LG3BP (galectin-3-binding protein), a potential marker in six cancer types, including HCC, lymphoma, NPC (nasopharyngeal carcinoma), CRC (colorectal carcinoma), and oral cancers [37].