The enrichment FDR values of 9, 13, 12 and 8 cancer modules (60%, 86.67%, 80%, 53.33%) calculated by the proposed method were lower than EMVC for HER2-enriched, Luminal A, Luminal B and Normal-like gene expression data respectively (Fig. 4b, d, f, h). The gene discussed is ERBB2; the disease is cancer.