Cell cycle:G1/S check point (FDR = 7.19e-03), PDGF receptor signaling network (FDR = 9.93e-03), RB tumor suppressor/checkpoint signaling in response to DNA damage (FDR = 0.02), and signaling by the TGF-beta receptor complex (FDR = 0.03) were significantly enriched in these genes but no amplification of CDK4. The gene discussed is CDK4; the disease is neoplasm.