ACHE and Alzheimer disease: In addition, we have reported that olive biophenols inhibited the enzymes including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine l-DOPA, which are involved in the pathogenesis AD [21].