LEP and neoplasm: Tumor cells themselves and tumor-associated stroma secrete angiogenesis-promoting factors such as angiopoietin-2, follistatin, G-CSF (granulocyte colony-stimulating factor), HGF (hepatocyte growth factor), IL-8 (Interleukin 8), leptin, PDGF-BB, PECAM-1, VEGF, and MMP-1, -2, -3, -7, -9, -10, -12, and -13 [34].