SEMA4A and cancer: On the other hand, the Sema4A pathways are dysregulated in different diseases such as retinal degenerative diseases (retinitis pigmentosa type 35 and cone-rod dystrophy type 10) [29], allergy [10,14,19,22,23], infectious [14,32] and autoimmune diseases [14,26,28], and certain types of cancer [16,33].