MYC and cancer: Over 40 years have passed since the discovery of MYC, a major oncogene that is estimated to contribute to at least 75% of all human cancers, including prostate, breast, colon and cervical cancers, myeloid leukemia, lymphomas, small-cell lung carcinomas, and neuroblastoma, among others, most of which are aggressive and respond poorly to the current therapies [1] (Figure 1).