MYC and posterior cortical atrophy: From 10 compounds that showed greater than 50% inhibition of Myc-Max transcriptional activity in LNCaP PCa cells, as determined by a commercially available luciferase-based Myc reporter assay that was utilized as a primary screen, VPC-70063 (Figure 11) showed the best inhibition of Myc activity with an IC50 of 8.9 μM and it was prioritized for further in vitro mechanistic evaluation.