Biological assays, including MTT, flow cytometry, RT-PCR, and luciferase-based reporter assays showed that TPP selectively induced apoptosis in T47D breast cancer cells with Myc overexpression, with no effect on normal kidney epithelial NKE cells by a mechanism involving the downregulation of Myc expression (at a 35 μM concentration) by arresting the Pu27 G4, thus interfering with MYC transcription [206]. The gene discussed is MYC; the disease is breast carcinoma.