It has been shown that, besides MYC, other major cancer driver genes form parallel G-quadruplex structures (G4s), including Bcl2, VEGFA (vascular endothelial growth factor A), c-KIT (KIT proto-oncogene receptor tyrosine kinase), and HIF1α, while other G4 types form in the promoter regions of KRAS, RB1, hTERT, and PDGFA genes, as well as at telomeric ends (e.g., h-Telo) and ribosomal DNA, all of which differ in their folding patterns, number of G-tetrads, loop length, and composition [167,171]. This evidence concerns the gene VEGFA and cancer.