MYC and urinary bladder carcinoma: In a follow-up study, Jeong et al. (2014) [124] showed that KSI-3716 blocked Myc-Max binding to target gene promoters and decreased Myc-mediated transcriptional activity at concentrations as low as 1 μM, as well as the expression of target genes, including cyclin D2, CDK4, and hTERT. KSI-3716 exerted cytotoxic effects on bladder cancer cells by inducing cell cycle arrest and apoptosis.