The substitution of the methyl group on the aryl amine moiety of compound 1 to a para-trifluoromethyl yielded the best derivative, DC-34, which showed enhanced affinity and ability to downregulate MYC transcription in multiple myeloma cells in a G4-depedent fashion without affecting the expression of relevant G4-driven oncogenes. The gene discussed is MYC; the disease is AL amyloidosis.