MYC and cancer: sAJM589 also showed a dose-dependent inhibition of various Myc-dependent cancer cell lines: Ramos (Burkitt’s lymphoma), HL-60 and KG1a (acute myeloid leukemia) with IC50s of 0.9, 1.2, and 0.8 μM, respectively, but had no effect on resting macrophages whose proliferation is independent of Myc activity.