NFKB1 and neoplasm: In a tail vein metastasis model with mammary tumor cell lines established from mouse mammary tumor virus-polyoma middle T-antigen-derived tumors, NF-κB activation in lung macrophages induced their reversion into an M1-phenotype with enhanced production of reactive oxygen species and increased tumor cell apoptosis, thereby reducing lung metastases, when it was activated at tumor cell colonization in lungs [69].