Thus, in the current study, the pivotal roles of miR-4500 and STAT3 was investigated in ursolic acid treated colorectal cancers, since miR-4500 is partially associated with STAT3 sequence according to the miRWalk database (http://zmf.umm.uni-heidelberg.de/apps/zmf/mirwalk). The gene discussed is STAT3; the disease is colorectal cancer.