TP53 and malignant colon neoplasm: Likewise, Pagliara et al. reported that 5-fluorouracil activated ribosomal protein L3 in HCT116 p53−/− colon cancer cells as a proapoptotic factor [32], while mutant p53 confers chemoresistance in non-small lung cancer cells via upregulation of Nrf2 expression [33] or L3 downregulation [34].