Of note, inhibition of miR-4500 using miR-4500 inhibitor reduced the apoptotic ability of ursolic acid to increase cytotoxicity and TUNEL positive cells and suppress the cleaved PARP and nuclear translocation of P-Jak2/p-STAT3 induced by ursolic acid in colorectal cancer cells, demonstrating the pivotal role of miR-4500 in apoptotic effect of ursolic acid via inhibition of Jak2/Stat3 signaling. Here, STAT3 is linked to colorectal cancer.