TP53 and colonic neoplasm: Additionally, though ursolic acid was known to induce apoptosis in several cancers such as lung cancer [16,17], breast cancer [18], prostate cancer [19], colon cancer [18], liver cancer [20], and melanoma [21] via phosphoinositide 3-kinase(PI3K)/AKT [22], EGFR/mitogen-activated protein kinase (MAPK) [23], p53 [24] and c-Jun N-terminal kinase (JNK) [25] pathways, the underlying mechanism of ursolic acid is not fully understood in colorectal cancers.