In addition to upregulation of Elongator, ALKBH8 and thiolase genes CTU1 and CTU2 genes, other tRNA modification genes, including NSUN2 (m5C) and METTL1 (m 7G) also become overexpressed in human cancers [52,54,154,155] (Table 1). This evidence concerns the gene NSUN2 and cancer.