HMGB1 and Sepsis: Furthermore, RA isolated from PFL could inhibit the release of high mobility group box 1 protein (HMGB1) and down-regulated HMGB1-dependent inflammatory responses in human endothelial cells, HMGB1-mediated hyperpermeability, and leukocyte migration in mice, as well as reduced cecal ligation and puncture (CLP)-induced HMGB1 release and sepsis-related mortality.