Hypertension of any grade according to CTCAE (Common Terminology Criteria for Adverse Events) is reported with an incidence ranging from 17% to 49.6% [4] depending on different TKI types, dosages, genetic polymorphisms of VEGF and VEGFR, age, body mass index (BMI), and pre-existing hypertension [5]. The gene discussed is KDR; the disease is Hypertension.