AGTRAP and obesity due to melanocortin 4 receptor deficiency: To this point, interestingly, researchers reported that decreased PVAT ‘browning’ in thoracic aortas of aging spontaneously hypertensive rats (8 wks vs. 16 wks) was associated with attenuated vasodilation effects of PVAT [43], but ATRAP in brown adipose tissue does not affect the development of obesity-related metabolic disorders [44].